Radionuclide Impurities in Cyclotron-produced Gallium-68 and Zirconium-89 for Positron Emission Tomography
A. M. Dabkowski, A. A. Al-Obaidi, W. D. Evans, C. Marshall
Cardiff University
Oral Presentation
The authors whose names are listed immediately below certify that they have NO affi liations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-fi nancial interest (such as personal or professional relationships, affi liations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.
Introduction
Radiopharmaceuticals labelled with 68Ga (half-life 68.0 minutes) and 89Zr (half-life 78.4 hours) are of considerable interest in positron emission tomography. The radionuclides are cyclotron-produced but unwanted nuclear reactions cre-ate longer-lived impurities, which may impact adversely on labelling efficiency, image quality and patient radiation dose.
The purpose of this study was to identify and quantify impurity radionuclides in the trial pro-duction of 68Ga and 89Zr.