High yield automated production of the positron emitting radioisotope 86Y using a biomedical cyclotron
Thien Dinh, Stan Poniger, Harris Panopoulos, Henri Tochon-Danguy, Andrew Scott
Department of Molecular Imaging & Therapy, Austin Health, Australia. Olivia Newton-John Cancer Research Institute, Australia.
Poster
No conflicts of interest to declare.
86Y (T1/2 = 14.74 h, 32% β+) has significant potential in theranostic applications as a simultaneous PET imaging partner to 90Y-labelled antibody therapy. Enriched Strontium-86 Oxide powder was bombarded with 13MeV protons to induce the 86Sr(p,n)86Y reaction. The irradiated target was then transported directly to the hotcell using an automated pneumatic transfer system and inserted as is into an in-house built module for dissolution and purification. Measurement of post-irradiation target mass has shown the target can withstand irradiation currents of up to 20µA without material losses. Activities of up to 1800MBq of purified 86Y was produced, using less than 30mg of 86SrO. Typically 75% of the total activity is recovered in the elution volume . Gamma spectra analysis using a HPGe detector has shown that the final purified solution con-tains activity fractions of 0.45% 87Y and 0.1% 88Y when normalised against 86Y, hence 86Y purity of 99.45% at EOS. The developed target preparation methodology has allowed for increased yields through stability at higher beam currents and minimising the amount of costly enriched target material needing to be used. Additionally, the methodology allowed for compatibility with an automated purification module.